Parkinson mice show functional and molecular changes in the gut long before motoric disease onset

Parkinson mice show functional and molecular changes in the gut long before motoric disease onset

Abstract Background There is increasing evidence that Parkinson’s disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical onset of the disease the majority of dopaminergic neurons in the midbrain is already destroyed, so that the la...

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Bibliographic Details
Main Authors: Manuela Gries, Anne Christmann, Steven Schulte, Maximilian Weyland, Stephanie Rommel, Monika Martin, Marko Baller, Ralph Röth, Stefanie Schmitteckert, Marcus Unger, Yang Liu, Frederik Sommer, Timo Mühlhaus, Michael Schroda, Jean-Pierre Timmermans, Isabel Pintelon, Gudrun A. Rappold, Markus Britschgi, Hilal Lashuel, Michael D. Menger, Matthias W. Laschke, Beate Niesler, Karl-Herbert Schäfer
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson’s disease
Early onset
Enteric nervous system
Gastrointestinal motility
Protein-and miRNA biomarkers
Online Access:https://doi.org/10.1186/s13024-021-00439-2

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