Chronic immune activation in HIV-1 infection contributes to reduced interferon alpha production via enhanced CD40:CD40 ligand interaction.

Chronic immune activation in HIV-1 infection contributes to reduced interferon alpha production via enhanced CD40:CD40 ligand interaction.

Although a signature of increased interferon (IFN-)alpha production is observed in HIV-1 infection, the response of circulating plasmacytoid dendritic cells (PDC) to Toll-like receptor ligand stimulation is substantially impaired. This functional PDC deficit, which we specifically observed in HIV-1...

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Bibliographic Details
Main Authors: Norbert Donhauser, Kathrin Pritschet, Martin Helm, Thomas Harrer, Philipp Schuster, Moritz Ries, Georg Bischof, Jörg Vollmer, Sigrun Smola, Barbara Schmidt, German Competence Network HIV/AIDS
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3309969?pdf=render

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