Tobacco Smoking Increases Methylation of Polypyrimidine Tract Binding Protein 1 Promoter in Intracranial Aneurysms

Tobacco Smoking Increases Methylation of Polypyrimidine Tract Binding Protein 1 Promoter in Intracranial Aneurysms

DNA methylation at the gene promoter region is reportedly involved in the development of intracranial aneurysm (IA). This study aims to investigate the methylation levels of polypyrimidine tract-binding protein 1 (PTBP1) in IA, as well as its potential to predict IA. Forty-eight patients with IA and...

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Bibliographic Details
Main Authors: Zhepei Wang, Shengjun Zhou, Jikuang Zhao, Sheng Nie, Jie Sun, Xiang Gao, Cameron Lenahan, Zhiqin Lin, Yi Huang, Gao Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
intracranal aneurysm
DNA Methylation
polypyrimidine tract binding protein 1
tobacco smoking
CpG island
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.688179/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.688179/full

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