Human Wharton’s Jelly Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Drive Oligodendroglial Maturation by Restraining MAPK/ERK and Notch Signaling Pathways

Human Wharton’s Jelly Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Drive Oligodendroglial Maturation by Restraining MAPK/ERK and Notch Signaling Pathways

Peripartum cerebral hypoxia and ischemia, and intrauterine infection and inflammation, are detrimental for the precursor cells of the myelin-forming oligodendrocytes in the prematurely newborn, potentially leading to white matter injury (WMI) with long-term neurodevelopmental sequelae. Previous data...

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Bibliographic Details
Main Authors: Marianne S. Joerger-Messerli, Gierin Thomi, Valérie Haesler, Irene Keller, Patricia Renz, Daniel V. Surbek, Andreina Schoeberlein
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mesenchymal stromal cells
Wharton’s jelly
small extracellular vesicles
premature white matter injury
oligodendroglial maturation
ERK
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.622539/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.622539/full

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