Distinct Gene Expression Patterns of Ion Channels and Cytokines in Rat Primary Sensory Neurons During Development of Bone Cancer and Cancer Pain

Distinct Gene Expression Patterns of Ion Channels and Cytokines in Rat Primary Sensory Neurons During Development of Bone Cancer and Cancer Pain

Cancer and cancer pain processes a major clinical challenge and the underlined mechanisms of pathogenesis remain elusive. We examined the specific changes in the transcriptomic profiles in the dorsal root ganglion (DRG) neurons of rats with bone cancer and bone cancer pain (BCP) using RNA sequencing...

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Bibliographic Details
Main Authors: Mingzhu Zhai, Shaomin Yang, Simin Lin, Hanxu Zhu, Lihong Xu, Huabao Liao, Xue-Jun Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cancer pain
dorsal root ganglion
RNA-sequence
cytokines
ion channels
neuropathic pain
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.665085/full

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