Noise genetics: inferring protein function by correlating phenotype with protein levels and localization in individual human cells.

Noise genetics: inferring protein function by correlating phenotype with protein levels and localization in individual human cells.

To understand gene function, genetic analysis uses large perturbations such as gene deletion, knockdown or over-expression. Large perturbations have drawbacks: they move the cell far from its normal working point, and can thus be masked by off-target effects or compensation by other genes. Here, we...

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Bibliographic Details
Main Authors: Shlomit Farkash-Amar, Anat Zimmer, Eran Eden, Ariel Cohen, Naama Geva-Zatorsky, Lydia Cohen, Ron Milo, Alex Sigal, Tamar Danon, Uri Alon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3945223?pdf=render

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