Quantification of Temozolomide in Nonhuman Primate Fluids by Isocratic Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry to Study Brain Tissue Penetration Following Intranasal or Intravenous Delivery

Quantification of Temozolomide in Nonhuman Primate Fluids by Isocratic Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry to Study Brain Tissue Penetration Following Intranasal or Intravenous Delivery

A sensitive and selective ultra-high performance liquid chromatography-tandem mass spectrometric method was developed for the quantification of temozolomide (TMZ) in nonhuman primate (NHP) plasma, cerebrospinal fluid (CSF), and brain extracellular fluid (ECF) following microdialysis. Ethyl acetate w...

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Bibliographic Details
Main Authors: Cody J. Peer, Lukas Ronner, Louis Rodgers, Cynthia M. Lester McCully, Katherine E. Warren, William D. Figg
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:Chromatography
Subjects:
ultra-high performance liquid chromatography
tandem mass spectrometry
temozolomide
nonhuman primates
Online Access:http://www.mdpi.com/2227-9075/3/1/4

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