Genomic Correlates of DNA Damage in Breast Cancer Subtypes

Genomic Correlates of DNA Damage in Breast Cancer Subtypes

Among the described druggable vulnerabilities, acting on the DNA repair mechanism has gained momentum, with the approval of PARP inhibitors in several indications, including breast cancer. However, beyond the mere presence of <i>BRCA1/BRCA2</i> mutations, the identification of additional...

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Bibliographic Details
Main Authors: Esther Cabañas Morafraile, Javier Pérez-Peña, Jesús Fuentes-Antrás, Aránzazu Manzano, Pedro Pérez-Segura, Atanasio Pandiella, Eva M. Galán-Moya, Alberto Ocaña
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
breast cancer
DNA damage response (DDR)
<i>ATR</i>
<i>Fanconi Anemia</i>
<i>ATM</i>
<i>BARD1</i>
Online Access:https://www.mdpi.com/2072-6694/13/9/2117

Internet

https://www.mdpi.com/2072-6694/13/9/2117

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