Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones
The first decarboxylative Mannich reaction employing β-keto acids, catalyzed by cinchonine-derived bifunctional thiourea catalyst has been described. The desired β-amino ketones were obtained in excellent yields and with moderate to good enantioselectivities.
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Beilstein-Institut
2012-08-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.8.144 |
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doaj-494619a3ad7e4b02a77ac13a92635ee42021-02-02T07:50:17ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972012-08-01811279128310.3762/bjoc.8.1441860-5397-8-144Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketonesChunhui Jiang0Fangrui Zhong1Yixin Lu2Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Republic of Singapore, 117543Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Republic of Singapore, 117543Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Republic of Singapore, 117543The first decarboxylative Mannich reaction employing β-keto acids, catalyzed by cinchonine-derived bifunctional thiourea catalyst has been described. The desired β-amino ketones were obtained in excellent yields and with moderate to good enantioselectivities.https://doi.org/10.3762/bjoc.8.144decarboxylative additionβ-keto acidMannich reactionorganocatalysis |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chunhui Jiang Fangrui Zhong Yixin Lu |
| spellingShingle |
Chunhui Jiang Fangrui Zhong Yixin Lu Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones Beilstein Journal of Organic Chemistry decarboxylative addition β-keto acid Mannich reaction organocatalysis |
| author_facet |
Chunhui Jiang Fangrui Zhong Yixin Lu |
| author_sort |
Chunhui Jiang |
| title |
Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones |
| title_short |
Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones |
| title_full |
Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones |
| title_fullStr |
Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones |
| title_full_unstemmed |
Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones |
| title_sort |
asymmetric organocatalytic decarboxylative mannich reaction using β-keto acids: a new protocol for the synthesis of chiral β-amino ketones |
| publisher |
Beilstein-Institut |
| series |
Beilstein Journal of Organic Chemistry |
| issn |
1860-5397 |
| publishDate |
2012-08-01 |
| description |
The first decarboxylative Mannich reaction employing β-keto acids, catalyzed by cinchonine-derived bifunctional thiourea catalyst has been described. The desired β-amino ketones were obtained in excellent yields and with moderate to good enantioselectivities. |
| topic |
decarboxylative addition β-keto acid Mannich reaction organocatalysis |
| url |
https://doi.org/10.3762/bjoc.8.144 |
| work_keys_str_mv |
AT chunhuijiang asymmetricorganocatalyticdecarboxylativemannichreactionusingbketoacidsanewprotocolforthesynthesisofchiralbaminoketones AT fangruizhong asymmetricorganocatalyticdecarboxylativemannichreactionusingbketoacidsanewprotocolforthesynthesisofchiralbaminoketones AT yixinlu asymmetricorganocatalyticdecarboxylativemannichreactionusingbketoacidsanewprotocolforthesynthesisofchiralbaminoketones |
| _version_ |
1724298523539668992 |