Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice

Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) is a candidate gene for the Down syndrome neurological defects and may be involved in the progression of Alzheimer's disease. Heterozygous mice for Dyrk1A (Dyrk1A+/−) exhibit decreased brain size, motor abnormalities and cognitive deficits...

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Bibliographic Details
Main Authors: Glòria Arqué, María Martínez de Lagrán, Maria L. Arbonés, Mara Dierssen
Format: Article
Language:English
Published: Elsevier 2009-11-01
Series:Neurobiology of Disease
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Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002022

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