Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice
Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) is a candidate gene for the Down syndrome neurological defects and may be involved in the progression of Alzheimer's disease. Heterozygous mice for Dyrk1A (Dyrk1A+/−) exhibit decreased brain size, motor abnormalities and cognitive deficits...
Main Authors: | Glòria Arqué, María Martínez de Lagrán, Maria L. Arbonés, Mara Dierssen |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2009-11-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996109002022 |
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