Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice

Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice

Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) is a candidate gene for the Down syndrome neurological defects and may be involved in the progression of Alzheimer's disease. Heterozygous mice for Dyrk1A (Dyrk1A+/−) exhibit decreased brain size, motor abnormalities and cognitive deficits...

Full description

Bibliographic Details
Main Authors: Glòria Arqué, María Martínez de Lagrán, Maria L. Arbonés, Mara Dierssen
Format: Article
Language:English
Published: Elsevier 2009-11-01
Series:Neurobiology of Disease
Subjects:
DYRK1A
Aging
Visuo-spatial learning and memory
Motor dysfunction
Radial-arm water maze
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002022
id doaj-493c0be50bb64e758d307d8f1f260ef3
record_format Article
spelling doaj-493c0be50bb64e758d307d8f1f260ef32021-03-20T04:58:05ZengElsevierNeurobiology of Disease1095-953X2009-11-01362312319Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant miceGlòria Arqué0María Martínez de Lagrán1Maria L. Arbonés2Mara Dierssen3Genes and Disease Program, Center for Genomic Regulation (CRG), Pompeu Fabra University, Barcelona Biomedical Research Park (PRBB) and CIBER de Enfermedades Raras (CIBERER), Barcelona, SpainGenes and Disease Program, Center for Genomic Regulation (CRG), Pompeu Fabra University, Barcelona Biomedical Research Park (PRBB) and CIBER de Enfermedades Raras (CIBERER), Barcelona, SpainGenes and Disease Program, Center for Genomic Regulation (CRG), Pompeu Fabra University, Barcelona Biomedical Research Park (PRBB) and CIBER de Enfermedades Raras (CIBERER), Barcelona, SpainCorresponding author. Center for Genomic Regulation (CRG) - Barcelona Biomedical Research Park (PRBB). Dr. Aiguadér, 88. E-08003 Barcelona, Spain. Fax: +34933160099.; Genes and Disease Program, Center for Genomic Regulation (CRG), Pompeu Fabra University, Barcelona Biomedical Research Park (PRBB) and CIBER de Enfermedades Raras (CIBERER), Barcelona, SpainDual-specificity tyrosine-regulated kinase 1A (DYRK1A) is a candidate gene for the Down syndrome neurological defects and may be involved in the progression of Alzheimer's disease. Heterozygous mice for Dyrk1A (Dyrk1A+/−) exhibit decreased brain size, motor abnormalities and cognitive deficits in the adult. However, there is no information about the mutant phenotype in old ages. Here we analyze the impact of Dyrk1A dosage reduction on motor performance and hippocampal-dependent learning and memory in aged Dyrk1A+/− mice. Whereas motor tests showed marked alterations in traction ability, prehensile reflex and balance, heterozygous mice only present a slight impairment of visuo-spatial memory even though they show a robust decrease of CA1–CA3 and dentate gyrus cells.http://www.sciencedirect.com/science/article/pii/S0969996109002022DYRK1AAgingVisuo-spatial learning and memoryMotor dysfunctionRadial-arm water maze
collection DOAJ
language English
format Article
sources DOAJ
author Glòria Arqué
María Martínez de Lagrán
Maria L. Arbonés
Mara Dierssen
spellingShingle Glòria Arqué
María Martínez de Lagrán
Maria L. Arbonés
Mara Dierssen
Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice
Neurobiology of Disease
DYRK1A
Aging
Visuo-spatial learning and memory
Motor dysfunction
Radial-arm water maze
author_facet Glòria Arqué
María Martínez de Lagrán
Maria L. Arbonés
Mara Dierssen
author_sort Glòria Arqué
title Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice
title_short Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice
title_full Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice
title_fullStr Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice
title_full_unstemmed Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice
title_sort age-associated motor and visuo-spatial learning phenotype in dyrk1a heterozygous mutant mice
publisher Elsevier
series Neurobiology of Disease
issn 1095-953X
publishDate 2009-11-01
description Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) is a candidate gene for the Down syndrome neurological defects and may be involved in the progression of Alzheimer's disease. Heterozygous mice for Dyrk1A (Dyrk1A+/−) exhibit decreased brain size, motor abnormalities and cognitive deficits in the adult. However, there is no information about the mutant phenotype in old ages. Here we analyze the impact of Dyrk1A dosage reduction on motor performance and hippocampal-dependent learning and memory in aged Dyrk1A+/− mice. Whereas motor tests showed marked alterations in traction ability, prehensile reflex and balance, heterozygous mice only present a slight impairment of visuo-spatial memory even though they show a robust decrease of CA1–CA3 and dentate gyrus cells.
topic DYRK1A
Aging
Visuo-spatial learning and memory
Motor dysfunction
Radial-arm water maze
url http://www.sciencedirect.com/science/article/pii/S0969996109002022
work_keys_str_mv AT gloriaarque ageassociatedmotorandvisuospatiallearningphenotypeindyrk1aheterozygousmutantmice
AT mariamartinezdelagran ageassociatedmotorandvisuospatiallearningphenotypeindyrk1aheterozygousmutantmice
AT marialarbones ageassociatedmotorandvisuospatiallearningphenotypeindyrk1aheterozygousmutantmice
AT maradierssen ageassociatedmotorandvisuospatiallearningphenotypeindyrk1aheterozygousmutantmice
_version_ 1724211550428856320

Similar Items