Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli

Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli

G-protein coupled receptor 3 (GPR3), GPR6, and GPR12 belong to a family of constitutively active Gs-coupled receptors that activate 3′-5′-cyclic adenosine monophosphate (cAMP) and are highly expressed in the brain. Among these receptors, the endogenous expression of GPR3 in cerebellar granule neuron...

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Bibliographic Details
Main Authors: Shigeru Tanaka, Tatsuhiro Miyagi, Eisuke Dohi, Takahiro Seki, Izumi Hide, Yusuke Sotomaru, Yoshinaga Saeki, E. Antonio Chiocca, Masayasu Matsumoto, Norio Sakai
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Neurobiology of Disease
Subjects:
GPR3
Brain ischemia
Cerebellar granular neurons
Neuronal protection
cAMP
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000965

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