Magnoflorine – a compound with anti-tumour activity

• Main Authors: Marzena Baran, Paulina Miziak, Katarzyna Bonio
• Format: Article
• Language: English
• Published: Institute of Rural Health 2020-09-01
• Series: Journal of Pre-Clinical and Clinical Research
• Subjects: biosynthesis; alkaloids; antitumour activity; magnoflorin
• Online Access: http://www.journalssystem.com/jpccr/Magnoflorin-compound-with-anti-tumor-activity,127326,0,2.html
• ISSN: 1898-2395; 1898-7516

Introduction Alkaloids are a large group of organic compounds of natural origin. One of the most popular alkaloids is magnoflorine. This compound is synthesized by plants from the Ranunculaceae, Menispermaceae and Magnoliaceae families. Magnoflorine has unique biological properties and a broad spectrum of physiotherapeutic activity. It has antibacterial, antifungal, antidiabetic, immunomodulating and anticancer properties. Objective The aim of the study is to present magnoflorine as a compound with anti-cancer potential. Brief description of the state of knowledge Magnoflorine is a compound belonging to the isoquinolone alkaloids. Metabolized by secondary metabolism it is most commonly collected in the roots, rhizomes, tubers and bark of plants. It can be isolated from all plant elements by chromatographic methods. Magnoflorine has a number of therapeutic properties, including anti-cancer. Magnoflorine has been shown to inhibit cell proliferation, migration and cause apoptosis. The possibility of using this compound in the treatment of breast and stomach cancer has been confirmed. Results The combination of DOX with magnoflorine reduces the expression of Bcl-2 and enhances the cleavage of caspase-9 and -3, causing apoptosis in breast cancer cells. Moreover, they block the activation of PI3K / AKT / mTOR signaling, which play an important role in regulating tumour growth. Magnoflorine inhibits the activity of caspases in liver cancer cells, resulting in inhibition of proliferation Conclusions Magnoflorine is an interesting research target due to its unique anticancer properties. Detailed knowledge of the pharmacological possibilities of magnoflorine will enable its effective use in the prevention and treatment of many civilization diseases.