Polyphenols vs. Coronaviruses: How Far Has Research Moved Forward?

The epidemic, caused by SARS-CoV-2 at the beginning of 2020, led us to a serious change in our lifestyle that for about three months has confined us to our homes, far from our laboratory routine. In this period, the belief that the work of a researcher should never stop has been the driving force in...

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Bibliographic Details
Main Authors: Simona Piccolella, Giuseppina Crescente, Shadab Faramarzi, Marialuisa Formato, Maria Tommasina Pecoraro, Severina Pacifico
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
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Online Access:https://www.mdpi.com/1420-3049/25/18/4103
Description
Summary:The epidemic, caused by SARS-CoV-2 at the beginning of 2020, led us to a serious change in our lifestyle that for about three months has confined us to our homes, far from our laboratory routine. In this period, the belief that the work of a researcher should never stop has been the driving force in writing the present paper. It aims at reviewing the recent scientific knowledge about in vitro experimental data that focused on the antiviral role of phenols and polyphenols against different species of coronaviruses (CoVs), pointing up the viral targets potentially involved. In the current literature scenario, the papain-like and the 3-chymotrypsin-like proteases seem to be the most deeply investigated and a number of isolated natural (poly)phenols has been screened for their efficacy.
ISSN:1420-3049