Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB.

Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB.

The long noncoding MALAT1 RNA is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation, but the underlying mechanism is poorly understood. We demonstrate that MALAT1 levels are regulated during normal cell cycle progression. Genome-wide transcriptome analys...

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Main Authors: Vidisha Tripathi, Zhen Shen, Arindam Chakraborty, Sumanprava Giri, Susan M Freier, Xiaolin Wu, Yongqing Zhang, Myriam Gorospe, Supriya G Prasanth, Ashish Lal, Kannanganattu V Prasanth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3605280?pdf=render

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