Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review

• Main Authors: Maryam Bashir, Afifa Bano, Abdul Subhan Ijaz, Bashir Ahmad Chaudhary
• Format: Article
• Language: English
• Published: MDPI AG 2015-07-01
• Series: Molecules
• Subjects: N-substituted carbazoles; antimicrobial; anticancer; neuroprotective
• Online Access: http://www.mdpi.com/1420-3049/20/8/13496

Carbazoles represent an important class of heterocycles. These have been reported to exhibit diverse biological activities such as antimicrobial, antitumor, antiepileptic, antihistaminic, antioxidative, anti-inflammatory, antidiarrhoeal, analgesic, neuroprotective and pancreatic lipase inhibition properties. A series of carbazole derivatives such as N-substituted carbazoles, benzocarbazoles, furocarbazoles, pyrrolocarbazoles, indolocarbazoles, imidazocarbazoles, etc. have been synthesized. The N-substituted derivatives have gained the attention of researchers due to their therapeutic potential against neurological disorders and cell proliferation. Herein an attempt is made to review the medicinal importance of recently synthesized N-substituted carbazoles.