Variable processing and cross-presentation of HIV by dendritic cells and macrophages shapes CTL immunodominance and immune escape.

Variable processing and cross-presentation of HIV by dendritic cells and macrophages shapes CTL immunodominance and immune escape.

Dendritic cells (DCs) and macrophages (Møs) internalize and process exogenous HIV-derived antigens for cross-presentation by MHC-I to cytotoxic CD8⁺ T cells (CTL). However, how degradation patterns of HIV antigens in the cross-presentation pathways affect immunodominance and immune escape is poorly...

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Bibliographic Details
Main Authors: Jens Dinter, Ellen Duong, Nicole Y Lai, Matthew J Berberich, Georgio Kourjian, Edith Bracho-Sanchez, Duong Chu, Hang Su, Shao Chong Zhang, Sylvie Le Gall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004725

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