Dietary supplementation with fructooligosaccharides ameliorates allergy development following DEHP exposure in mice
Fructooligosaccharides (FOS), a prebiotic supplement, can enhance immunological responses, probably through regulation of gastrointestinal microflora. On the other hand, some environmental pollutants have adjuvanticity against allergic reactions/diseases. The purpose of this study was to evaluate th...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
|
| Series: | Food and Agricultural Immunology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09540105.2021.1952934 |
| Summary: | Fructooligosaccharides (FOS), a prebiotic supplement, can enhance immunological responses, probably through regulation of gastrointestinal microflora. On the other hand, some environmental pollutants have adjuvanticity against allergic reactions/diseases. The purpose of this study was to evaluate the effects of dietary supplementation with FOS on a murine model of enhanced ovalbumin (OVA)-related allergic peritonitis induced by di-(2-ethylhexyl) phthalate (DEHP). C3H/HeN mice were intraperitoneally administered OVA and DEHP, and fed a diet containing 2.5% FOS. Thereafter, several parameters were evaluated. Supplementation with FOS alleviated OVA plus DEHP-related peritoneal inflammation characterized by infiltration of polymorphonuclear leukocytes including neutrophils in the peritoneal cavity. Also, FOS administration declined the number of mast cells of OVA + DEHP treated mice. FOS suppressed the elevated protein level of interleukin-5, eotaxin, and keratinocyte-derived chemoattractant, in the peritoneal lavage fluids. Our results suggest that dietary supplementation with FOS can prevent or ameliorate enhanced allergic peritoneal inflammation induced by DEHP. |
|---|---|
| ISSN: | 0954-0105 1465-3443 |