Application and Characterization of Gum from <em>Bombax buonopozense </em>Calyxes<em> </em>as an Excipient in Tablet Formulation

• Main Authors: Onyinye J. Uwaezuoke, Ndidi C. Ngwuluka, Jehu Kyari, John Taplong
• Format: Article
• Language: English
• Published: MDPI AG 2012-08-01
• Series: Pharmaceutics
• Subjects: tablets; tablet manufacture; natural gums; <em>Bombax buonopozense</em> drug delivery; zero order; controlled release; dosage forms; oral delivery
• Online Access: http://www.mdpi.com/1999-4923/4/3/354

This study was undertaken to explore gum from <em>Bombax buonopozense </em>calyxes as a binding agent in formulation of immediate release dosage forms using wet granulation method. The granules were characterized to assess the flow and compression properties and when compressed, non-compendial and compendial tests were undertaken to assess the tablet properties for tablets prepared with bombax gum in comparison with those prepared with tragacanth and acacia gums. Granules prepared with bombax exhibited good flow and compressible properties with angle of repose 28.60°, Carr’s compressibility of 21.30% and Hausner’s quotient of 1.27. The tablets were hard, but did not disintegrate after one hour. Furthermore, only 52.5% of paracetamol was released after one hour. The drug release profile followed zero order kinetics. Tablets prepared with bombax gum have the potential to deliver drugs in a controlled manner over a prolonged period at a constant rate.