Hyaluronan Immobilized Polyurethane as a Blood Contacting Material

Hyaluronan Immobilized Polyurethane as a Blood Contacting Material

Hyaluronan (hyaluronic acid, HA) was immobilized onto the surface of amino-functionalized polyurethane films with the goal of obtaining a novel kind of biomaterial which had the potential in blood-contacting applications. The amino-functionalized polyurethane was prepared by synthesized acidic polyu...

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Main Authors: Feirong Gong, Yue Lu, Hui Guo, Shujun Cheng, Yun Gao
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:International Journal of Polymer Science
Online Access:http://dx.doi.org/10.1155/2010/807935
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spelling doaj-48fb7bc5d1aa4c829b4a220dca7267ad2020-11-25T00:37:38ZengHindawi LimitedInternational Journal of Polymer Science1687-94221687-94302010-01-01201010.1155/2010/807935807935Hyaluronan Immobilized Polyurethane as a Blood Contacting MaterialFeirong Gong0Yue Lu1Hui Guo2Shujun Cheng3Yun Gao4Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, ChinaHyaluronan (hyaluronic acid, HA) was immobilized onto the surface of amino-functionalized polyurethane films with the goal of obtaining a novel kind of biomaterial which had the potential in blood-contacting applications. The amino-functionalized polyurethane was prepared by synthesized acidic polyurethane whose pendant carboxyl groups were treated with an excess amount of 1,3-diaminopropane in the presence of N,N-carbonyldiimidazole (CDI). Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), Raman spectroscopy (RS), scanning electron microscopy (SEM), and water contact angle measurement were used to confirm the surface changes at each step of treatment, both in morphologies and chemical compositions. APTT and PT results showed that HA immobilization could prolong the blood coagulation time, thus HA-immobilized polyurethane (PU-HA) exhibited improved blood compatibility. Cytotoxicity analysis showed that the PU-HA films synthesized in this study were cytocompatible and could support human vein endothelial cells (HUVECs) adhesion and proliferation.http://dx.doi.org/10.1155/2010/807935
collection DOAJ
language English
format Article
sources DOAJ
author Feirong Gong
Yue Lu
Hui Guo
Shujun Cheng
Yun Gao
spellingShingle Feirong Gong
Yue Lu
Hui Guo
Shujun Cheng
Yun Gao
Hyaluronan Immobilized Polyurethane as a Blood Contacting Material
International Journal of Polymer Science
author_facet Feirong Gong
Yue Lu
Hui Guo
Shujun Cheng
Yun Gao
author_sort Feirong Gong
title Hyaluronan Immobilized Polyurethane as a Blood Contacting Material
title_short Hyaluronan Immobilized Polyurethane as a Blood Contacting Material
title_full Hyaluronan Immobilized Polyurethane as a Blood Contacting Material
title_fullStr Hyaluronan Immobilized Polyurethane as a Blood Contacting Material
title_full_unstemmed Hyaluronan Immobilized Polyurethane as a Blood Contacting Material
title_sort hyaluronan immobilized polyurethane as a blood contacting material
publisher Hindawi Limited
series International Journal of Polymer Science
issn 1687-9422
1687-9430
publishDate 2010-01-01
description Hyaluronan (hyaluronic acid, HA) was immobilized onto the surface of amino-functionalized polyurethane films with the goal of obtaining a novel kind of biomaterial which had the potential in blood-contacting applications. The amino-functionalized polyurethane was prepared by synthesized acidic polyurethane whose pendant carboxyl groups were treated with an excess amount of 1,3-diaminopropane in the presence of N,N-carbonyldiimidazole (CDI). Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), Raman spectroscopy (RS), scanning electron microscopy (SEM), and water contact angle measurement were used to confirm the surface changes at each step of treatment, both in morphologies and chemical compositions. APTT and PT results showed that HA immobilization could prolong the blood coagulation time, thus HA-immobilized polyurethane (PU-HA) exhibited improved blood compatibility. Cytotoxicity analysis showed that the PU-HA films synthesized in this study were cytocompatible and could support human vein endothelial cells (HUVECs) adhesion and proliferation.
url http://dx.doi.org/10.1155/2010/807935
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AT yuelu hyaluronanimmobilizedpolyurethaneasabloodcontactingmaterial
AT huiguo hyaluronanimmobilizedpolyurethaneasabloodcontactingmaterial
AT shujuncheng hyaluronanimmobilizedpolyurethaneasabloodcontactingmaterial
AT yungao hyaluronanimmobilizedpolyurethaneasabloodcontactingmaterial
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