Noncanonical Inhibition of mTORC1 by Coxiella burnetii Promotes Replication within a Phagolysosome-Like Vacuole

Noncanonical Inhibition of mTORC1 by Coxiella burnetii Promotes Replication within a Phagolysosome-Like Vacuole

Coxiella burnetii is an intracellular pathogenic bacterium that replicates within a lysosomal vacuole. Biogenesis of the Coxiella-containing vacuole (CCV) requires effector proteins delivered into the host cell cytosol by the type 4B secretion system (T4BSS). Modifications to lysosomal physiology re...

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Bibliographic Details
Main Authors: Charles L. Larson, Kelsi M. Sandoz, Diane C. Cockrell, Robert A. Heinzen
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mBio
Subjects:
Coxiella
Q fever
autophagy
coxiella-containing vacuole
endolysosomal membranes
lysosome
mTor
type IV secretion
vacuole
Online Access:https://doi.org/10.1128/mBio.02816-18

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