Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice

Brain structures differ in the magnitude of age-related neuron loss with the cerebellum being more affected. An underlying cause could be an age-related decline in mitochondrial bioenergetics. Successful aging of mitochondria reflects a balanced turnover of proteins involved in mitochondrial biogene...

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Bibliographic Details
Main Authors: Aurel Popa-Wagner, Raluca E. Sandu, Coman Cristin, Adriana Uzoni, Kevin A. Welle, Jennifer R. Hryhorenko, Sina Ghaemmaghami
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2018.00032/full