MCAM/CD146 Signaling via PLCγ1 Leads to Activation of β1-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration

MCAM/CD146 Signaling via PLCγ1 Leads to Activation of β1-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration

Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and cause neurodegenerative inflammation. To enter the tar...

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Bibliographic Details
Main Authors: Lisa Zondler, Sebastian Herich, Petra Kotte, Katharina Körner, Tilman Schneider-Hohendorf, Heinz Wiendl, Nicholas Schwab, Alexander Zarbock
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
integrin
T-cell
adhesion
recruitment
multiple sclerosis
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.599936/full

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