How Can Biomolecules Improve Mucoadhesion of Oral Insulin? A Comprehensive Insight using <i>Ex-Vivo</i>, <i>In Silico</i>, and <i>In Vivo</i> Models

How Can Biomolecules Improve Mucoadhesion of Oral Insulin? A Comprehensive Insight using <i>Ex-Vivo</i>, <i>In Silico</i>, and <i>In Vivo</i> Models

Currently, insulin can only be administered through the subcutaneous route. Due to the flaws associated with this route, it is of interest to orally deliver this drug. However, insulin delivered orally has several barriers to overcome as it is degraded by the stomach’s low pH, enzymatic content, and...

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Bibliographic Details
Main Authors: Mariana Amaral, Ana Sofia Martins, José Catarino, Pedro Faísca, Pradeep Kumar, João F. Pinto, Rui Pinto, Isabel Correia, Lia Ascensão, Ricardo A. Afonso, M. Manuela Gaspar, Adília J. Charmier, Isabel Vitória Figueiredo, Catarina Pinto Reis
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
marine-derived biomolecules
diabetes mellitus
insulin
mucoadhesion
nanoparticle
oral delivery
Online Access:https://www.mdpi.com/2218-273X/10/5/675

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