Gold Electrodes Modified with Calix[4]arene for Electrochemical Determination of Dopamine in the Presence of Selected Neurotransmitters

• Main Authors: Katarzyna Kurzątkowska, Serkan Sayin, Mustafa Yilmaz, Hanna Radecka, Jerzy Radecki
• Format: Article
• Language: English
• Published: MDPI AG 2017-06-01
• Series: Sensors
• Subjects: calix[4]arene; neurotransmitters; dopamine; norepinephrine; epinephrine; molecular recognition; voltammetric sensors
• Online Access: http://www.mdpi.com/1424-8220/17/6/1368
• ISSN: 1424-8220

Here, we present an electrochemical sensor based on gold electrodes modified with calix[4]arene functionalized with carboxypiperidino groups at the upper rim. It has been demonstrated that these groups are involved in a complex formation with dopamine (DA) on the surface of gold electrodes. The supramolecular complex calix[4]arene–DA created on the gold electrode surface has been characterized electrochemically and the measuring conditions have been optimized. The presented sensor displayed a detection limit in the pM range. The DA determination was performed successfully in the presence of ascorbic acid, uric acid and selected neurotransmitters.