Etiological features of onychomycosis in the Krasnodar territory. Choice of method systemic therapy

• Main Authors: M. M. Tlish, T. G. Kuznetsova, F. A. Psavok
• Format: Article
• Language: Russian
• Published: State Scientific Center of Dermatovenereology and Cosmetology 2017-08-01
• Series: Vestnik Dermatologii i Venerologii
• Subjects: онихомикоз; этиология; системная терапия; итраконазол (ирунин); эффективность; безопасность; onychomycosis; etiology; systemic therapy; itraconazole (irunine); efficacy; safety
• Online Access: https://www.vestnikdv.ru/jour/article/view/275

Successful treatment of onychomycosis associated with the necessity of microbiological research aimed at the selection of culture with proven etiological significance. Features of morphological and functional characteristics of the nail, poly etiology of onychomycosis, the availability of labor input in the use of topical antifungal drugs and irrational approaches to the treatment of various forms of the disease, as well as the duration and high cost of treatment create difficulties in the treatment of this contingent of patients . Goal. To study the etiology of onychomycosis in the Krasnodar region, and a comparative analysis of the efficacy and tolerability of antifungal drug regimens "Irunine". Materials and methods. A total of 64 patients (39 men and 25 women) with complaints about the change of nail plates in the hands and feet. The diagnosis of onychomycosis was established for 46 (71.88%) patients, of which 2 patients in the study group were not included. The rest were randomly selected and divided into 2 equivalent groups of 22 patients. Patients of the 1st group received "Irunine" by the method of pulse - therapy, and the patients in group 2 on continuous therapy scheme. Results. In the study of the samples from the nail plates, the major causative agent of onychomycosis was T. rubrum - 61,37%. Candida spp. was diagnosed in 11%. Equally often - at 9.09%, were the growth of T. mentagrophytes var. interdigitale and T. tonsurans. Furthermore, associations have been identified T. rubrum and Candida albicans - 6,82%, T. rubrum and Aspergillus versicolor - 2,27%. The result of our study showed a high clinical and mycological efficacy of the drug "Irunine" in the treatment of onychomycosis. Comparative analysis of this drug therapy results showed that the method of pulse therapy, compared with continuous therapy scheme is more efficient and economically advantageous, since it allows to reduce the amount of drugs, and therefore significantly reduce the risk of adverse reactions and improve its tolerability. Conclusion. The findings suggest that the leading position in patients with onychomycosis mycobiota hold dermatomitsetami genus Trichophyton. Pulse therapy with "Irunine" is a priority and can be recommended for use as a systemic drug for the treatment of onychomycosis, as a highly effective and safe drug.