Preregistration of exploratory research: Learning from the golden age of discovery.

Preregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides rating the research question and soundness of methodology over outstanding significance of the results, they can help with antagonizing inad...

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Main Author: Ulrich Dirnagl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000690
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spelling doaj-48ba75f0ff964d99af4c5b02d4765e422021-07-02T16:27:03ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852020-03-01183e300069010.1371/journal.pbio.3000690Preregistration of exploratory research: Learning from the golden age of discovery.Ulrich DirnaglPreregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides rating the research question and soundness of methodology over outstanding significance of the results, they can help with antagonizing inadequate statistical power, selective reporting of results, undisclosed analytic flexibility, as well as publication bias. Preregistration works well when a clear hypothesis, primary outcome, and mode of analysis can be formulated. But is it also applicable and useful in discovery research, which develops theories and hypotheses, measurement techniques, and generates evidence that justifies further research? I will argue that only slight modifications are needed to harness the potential of preregistration and make exploratory research more trustworthy and useful.https://doi.org/10.1371/journal.pbio.3000690
collection DOAJ
language English
format Article
sources DOAJ
author Ulrich Dirnagl
spellingShingle Ulrich Dirnagl
Preregistration of exploratory research: Learning from the golden age of discovery.
PLoS Biology
author_facet Ulrich Dirnagl
author_sort Ulrich Dirnagl
title Preregistration of exploratory research: Learning from the golden age of discovery.
title_short Preregistration of exploratory research: Learning from the golden age of discovery.
title_full Preregistration of exploratory research: Learning from the golden age of discovery.
title_fullStr Preregistration of exploratory research: Learning from the golden age of discovery.
title_full_unstemmed Preregistration of exploratory research: Learning from the golden age of discovery.
title_sort preregistration of exploratory research: learning from the golden age of discovery.
publisher Public Library of Science (PLoS)
series PLoS Biology
issn 1544-9173
1545-7885
publishDate 2020-03-01
description Preregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides rating the research question and soundness of methodology over outstanding significance of the results, they can help with antagonizing inadequate statistical power, selective reporting of results, undisclosed analytic flexibility, as well as publication bias. Preregistration works well when a clear hypothesis, primary outcome, and mode of analysis can be formulated. But is it also applicable and useful in discovery research, which develops theories and hypotheses, measurement techniques, and generates evidence that justifies further research? I will argue that only slight modifications are needed to harness the potential of preregistration and make exploratory research more trustworthy and useful.
url https://doi.org/10.1371/journal.pbio.3000690
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