A synthetic HIV-1 subtype C backbone generates comparable PR and RT resistance profiles to a subtype B backbone in a recombinant virus assay.

A synthetic HIV-1 subtype C backbone generates comparable PR and RT resistance profiles to a subtype B backbone in a recombinant virus assay.

In order to determine phenotypic protease and reverse transcriptase inhibitor-associated resistance in HIV subtype C virus, we have synthetically constructed an HIV-1 subtype C (HIV-1-C) viral backbone for use in a recombinant virus assay. The in silico designed viral genome was divided into 4 fragm...

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Bibliographic Details
Main Authors: David Nauwelaers, Margriet Van Houtte, Bart Winters, Kim Steegen, Kurt Van Baelen, Ellen Chi, Mimi Zhou, Derek Steiner, Rachelle Bonesteel, Colin Aston, Lieven J Stuyver
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3101197?pdf=render

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http://europepmc.org/articles/PMC3101197?pdf=render

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