Panton-Valentine Leucocidin Proves Direct Neuronal Targeting and Its Early Neuronal and Glial Impacts a Rabbit Retinal Explant Model

Panton-Valentine Leucocidin Proves Direct Neuronal Targeting and Its Early Neuronal and Glial Impacts a Rabbit Retinal Explant Model

Panton-Valentine leukocidin (PVL) retinal intoxication induces glial activation and inflammatory response via the interaction with retinal neurons. In this study, rabbit retinal explant was used as a model to study neuronal and glial consequences of PVL intoxication. Retinal explants were treated wi...

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Bibliographic Details
Main Authors: XuanLi Liu, Michel J Roux, Serge Picaud, Daniel Keller, Arnaud Sauer, Pauline Heitz, Gilles Prévost, David Gaucher
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Toxins
Subjects:
Panton-Valentine leukocidin
apoptosis
Müller cell activation
microglial cell activation
retinal explant
Online Access:https://www.mdpi.com/2072-6651/10/11/455

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