Evaluation of in vitro and in vivo immunostimulatory activities of poly (lactic-co-glycolic acid) nanoparticles loaded with soluble and autoclaved Leishmania infantum antigens: A novel vaccine candidate against visceral leishmaniasis

Evaluation of in vitro and in vivo immunostimulatory activities of poly (lactic-co-glycolic acid) nanoparticles loaded with soluble and autoclaved Leishmania infantum antigens: A novel vaccine candidate against visceral leishmaniasis

Objective: To prepare and characterize poly lactic-co-glycolic acid (PLGA) nanoparticles loaded with soluble leishmanial antigen or autoclaved leishmanial antigen and explore in vitro and in vivo immunogenicity of antigen encapsulated nanoparticles. Methods: Water/oil/water double emulsion technique...

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Bibliographic Details
Main Authors: Emrah Sefik Abamor, Adil Allahverdiyev, Ozlem Ayse Tosyali, Melahat Bagirova, Tayfun Acar, Zeynep Mustafaeva, Serap Derman
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Asian Pacific Journal of Tropical Medicine
Subjects:
visceral leishmaniasis
vaccine
delivery
immunostimulant
poly lactic-co-glycolic acid (plga)
nanoparticle
Online Access:http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=8;spage=353;epage=364;aulast=Abamor

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