Efficient synthesis of sulfonamide derivatives on solid supports catalyzed using solvent-free and microwave-assisted methods

• Main Authors: Argelia Camargo-Ordoñez, Christian Moreno-Reyes, Fabián Olazarán-Santibáñez, Sheila Martínez-Hernández, Virgilio Bocanegra-García, Gildardo Rivera
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2011-01-01
• Series: Química Nova
• Subjects: synthesis; sulfonamide; solid supports
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000500011&lng=en&tlng=en
• ISSN: 1678-7064

In this work we report the synthesis of sulfonamide derivatives using a conventional procedure and with solid supports, such as silica gel, florisil, alumina, 4Å molecular sieves, montmorillonite KSF, and montmorillonite K10 using solvent-free and microwave-assisted methods. Our results show that solid supports have a catalytic activity in the formation of sulfonamide derivatives. We found that florisil, montmorillonite KSF, and K10 could be used as inexpensive alternative catalysts that are easily separated from the reaction media. Additionally, solvent-free and microwave-assisted methods were more efficient in reducing reaction time and in increasing yield.