Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization

Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization

Tuberculosis (TB) is a global public health problem, which is caused by Mycobacterium tuberculosis (Mtb). Type 2 diabetes mellitus (T2DM) is one of the leading predisposing factors for development of TB after HIV/AIDS. Glibenclamide is a widely used anti-diabetic drug in low and middle-income countr...

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Bibliographic Details
Main Authors: Chidchamai Kewcharoenwong, Satria A. Prabowo, Gregory J. Bancroft, Helen A. Fletcher, Ganjana Lertmemongkolchai
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
glibenclamide
Mycobacterium tuberculosis
monocyte
diabetes mellitus
M2 polarization
anti-diabetic drug
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02109/full

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