Relation of Endothelin-1 with ophthalmologic blinding diseases
Endothelin-1(ET-1)is a vasoactive peptide containing 21 amino acids.It is currently considered as the most powerful vasoconstrictor. It not only plays a strong role in the contraction of blood vessels, but also can promote the inflammation. Besides its effects for cardiovascular, urinary, respirator...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2016-01-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2016/1/201601020.pdf |
| Summary: | Endothelin-1(ET-1)is a vasoactive peptide containing 21 amino acids.It is currently considered as the most powerful vasoconstrictor. It not only plays a strong role in the contraction of blood vessels, but also can promote the inflammation. Besides its effects for cardiovascular, urinary, respiratory, digestion, nervous, reproduction, endocrine system, it also plays a very important role in ophthalmologic blinding diseases. For example, ET-1 in eye mainly distributed in the choroid and it has a relation with cataract development, increased intraocular pressure of glaucoma and optic nerve damage. ET- 1 has certain effect on the maintenance of micro vascular homeostasis in diabetic retinopathy(DR)and its diagnosis; in non-arteritis anterior ischemic optic neuropathy, the level of ET-1 concentration is consistent with the severity of the lesion. On condition judgment for diseases and prognosis evaluation, it has certain clinical significance. With the study of the mechanism of ET-1 in these diseases, the prevention and treatment of ophthalmologic diseases will gain great benefit in the future. |
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| ISSN: | 1672-5123 1672-5123 |