A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus

A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus

Interferon (IFN)-sensitive and replication-incompetent influenza viruses are likely to be the alternatives to inactivated and attenuated virus vaccines. Some IFN-sensitive influenza vaccine candidates with modified non-structural protein 1 (NS1) are highly attenuated in IFN-competent hosts but induc...

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Bibliographic Details
Main Authors: Can Chen, Wenhui Fan, Jing Li, Weinan Zheng, Shuang Zhang, Limin Yang, Di Liu, Wenjun Liu, Lei Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Influenza A virus
vero cell line
NS1
interferon
vaccine
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00127/full

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