The CINs of Polo-Like Kinase 1 in Cancer

The CINs of Polo-Like Kinase 1 in Cancer

Polo-like kinase 1 (PLK1) is overexpressed near ubiquitously across all cancer types and dysregulation of this enzyme is closely tied to increased chromosomal instability and tumor heterogeneity. PLK1 is a mitotic kinase with a critical role in maintaining chromosomal integrity through its function...

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Bibliographic Details
Main Authors: Chelsea E. Cunningham, Mackenzie J. MacAuley, Frederick S. Vizeacoumar, Omar Abuhussein, Andrew Freywald, Franco J. Vizeacoumar
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
Polo-like kinase 1
chromosomal instability
DNA damage repair
synthetic dosage lethality
Online Access:https://www.mdpi.com/2072-6694/12/10/2953

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