Beneficial effects of a chlorophyll-rich spinach extract supplementation on prevention of obesity and modulation of gut microbiota in high-fat diet-fed mice

Beneficial effects of a chlorophyll-rich spinach extract supplementation on prevention of obesity and modulation of gut microbiota in high-fat diet-fed mice

Obesity has become a serious public health threat worldwide and recent evidence demonstrates that gut microbiota plays an important role in obesity. To the best of our knowledge, no research has been presented demonstrating the effects of a chlorophyll-rich spinach extract supplementation on obesity...

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Main Authors: Yuanyuan Li, Yu Cui, Feng Lu, Xiao Wang, Xiaojun Liao, Xiaosong Hu, Yan Zhang
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Journal of Functional Foods
Subjects:
A chlorophyll-rich spinach extract
High-fat diet
Obesity
Gut Microbiota
Lipopolysaccharide
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464619303603
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record_format Article
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language English
format Article
sources DOAJ
author Yuanyuan Li
Yu Cui
Feng Lu
Xiao Wang
Xiaojun Liao
Xiaosong Hu
Yan Zhang
spellingShingle Yuanyuan Li
Yu Cui
Feng Lu
Xiao Wang
Xiaojun Liao
Xiaosong Hu
Yan Zhang
Beneficial effects of a chlorophyll-rich spinach extract supplementation on prevention of obesity and modulation of gut microbiota in high-fat diet-fed mice
Journal of Functional Foods
A chlorophyll-rich spinach extract
High-fat diet
Obesity
Gut Microbiota
Lipopolysaccharide
author_facet Yuanyuan Li
Yu Cui
Feng Lu
Xiao Wang
Xiaojun Liao
Xiaosong Hu
Yan Zhang
author_sort Yuanyuan Li
title Beneficial effects of a chlorophyll-rich spinach extract supplementation on prevention of obesity and modulation of gut microbiota in high-fat diet-fed mice
title_short Beneficial effects of a chlorophyll-rich spinach extract supplementation on prevention of obesity and modulation of gut microbiota in high-fat diet-fed mice
title_full Beneficial effects of a chlorophyll-rich spinach extract supplementation on prevention of obesity and modulation of gut microbiota in high-fat diet-fed mice
title_fullStr Beneficial effects of a chlorophyll-rich spinach extract supplementation on prevention of obesity and modulation of gut microbiota in high-fat diet-fed mice
title_full_unstemmed Beneficial effects of a chlorophyll-rich spinach extract supplementation on prevention of obesity and modulation of gut microbiota in high-fat diet-fed mice
title_sort beneficial effects of a chlorophyll-rich spinach extract supplementation on prevention of obesity and modulation of gut microbiota in high-fat diet-fed mice
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2019-09-01
description Obesity has become a serious public health threat worldwide and recent evidence demonstrates that gut microbiota plays an important role in obesity. To the best of our knowledge, no research has been presented demonstrating the effects of a chlorophyll-rich spinach extract supplementation on obesity and associated changes in gut microflora of mice. The present study found that a chlorophyll-rich spinach extract supplementation effectively alleviated body weight gain and low-grade inflammation, and improved the glucose tolerance in HFD-fed mice (p < 0.05). High-throughput sequencing of the 16S rRNA showed the chlorophyll-rich spinach extract supplementation reversed HFD-induced gut microbiota dysbiosis, which was likely associated with the increased abundance of norank_f_Bacteroidales_S24-7_group and Akkermansia, and the decreased abundance of Lactobacillus and Lactococcus in mice. Taken together, this study suggested that the prevention of obesity by the chlorophyll-rich spinach extract supplementation was at least partially mediated by structural modulation of gut microbiota.
topic A chlorophyll-rich spinach extract
High-fat diet
Obesity
Gut Microbiota
Lipopolysaccharide
url http://www.sciencedirect.com/science/article/pii/S1756464619303603
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spelling doaj-4882de73e35a4ef195c9baffb6eb78ef2021-04-30T07:16:53ZengElsevierJournal of Functional Foods1756-46462019-09-0160Beneficial effects of a chlorophyll-rich spinach extract supplementation on prevention of obesity and modulation of gut microbiota in high-fat diet-fed miceYuanyuan Li0Yu Cui1Feng Lu2Xiao Wang3Xiaojun Liao4Xiaosong Hu5Yan Zhang6College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; National Engineering Research Center for Fruits and Vegetables Processing, Ministry of Science and Technology, Beijing 100083, China; Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture and Rural Affairs, Beijing 100083, China; Beijing Key Laboratory of Food Non-Thermal Processing, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; National Engineering Research Center for Fruits and Vegetables Processing, Ministry of Science and Technology, Beijing 100083, China; Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture and Rural Affairs, Beijing 100083, China; Beijing Key Laboratory of Food Non-Thermal Processing, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; National Engineering Research Center for Fruits and Vegetables Processing, Ministry of Science and Technology, Beijing 100083, China; Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture and Rural Affairs, Beijing 100083, China; Beijing Key Laboratory of Food Non-Thermal Processing, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; National Engineering Research Center for Fruits and Vegetables Processing, Ministry of Science and Technology, Beijing 100083, China; Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture and Rural Affairs, Beijing 100083, China; Beijing Key Laboratory of Food Non-Thermal Processing, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; National Engineering Research Center for Fruits and Vegetables Processing, Ministry of Science and Technology, Beijing 100083, China; Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture and Rural Affairs, Beijing 100083, China; Beijing Key Laboratory of Food Non-Thermal Processing, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; National Engineering Research Center for Fruits and Vegetables Processing, Ministry of Science and Technology, Beijing 100083, China; Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture and Rural Affairs, Beijing 100083, China; Beijing Key Laboratory of Food Non-Thermal Processing, Beijing 100083, ChinaCorresponding author at: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; National Engineering Research Center for Fruits and Vegetables Processing, Ministry of Science and Technology, Beijing 100083, China; Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture and Rural Affairs, Beijing 100083, China; Beijing Key Laboratory of Food Non-Thermal Processing, Beijing 100083, ChinaObesity has become a serious public health threat worldwide and recent evidence demonstrates that gut microbiota plays an important role in obesity. To the best of our knowledge, no research has been presented demonstrating the effects of a chlorophyll-rich spinach extract supplementation on obesity and associated changes in gut microflora of mice. The present study found that a chlorophyll-rich spinach extract supplementation effectively alleviated body weight gain and low-grade inflammation, and improved the glucose tolerance in HFD-fed mice (p < 0.05). High-throughput sequencing of the 16S rRNA showed the chlorophyll-rich spinach extract supplementation reversed HFD-induced gut microbiota dysbiosis, which was likely associated with the increased abundance of norank_f_Bacteroidales_S24-7_group and Akkermansia, and the decreased abundance of Lactobacillus and Lactococcus in mice. Taken together, this study suggested that the prevention of obesity by the chlorophyll-rich spinach extract supplementation was at least partially mediated by structural modulation of gut microbiota.http://www.sciencedirect.com/science/article/pii/S1756464619303603A chlorophyll-rich spinach extractHigh-fat dietObesityGut MicrobiotaLipopolysaccharide

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