An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development

An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development

Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is dependent on EGFR/RAS but not AGO2, while AGO2 is requir...

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Bibliographic Details
Main Authors: Sunita Shankar, Jean Ching-Yi Tien, Ronald F. Siebenaler, Seema Chugh, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Xiao-Ming Wang, Ingrid J. Apel, Jessica Waninger, Sanjana Eyunni, Alice Xu, Malay Mody, Andrew Goodrum, Yuping Zhang, John J. Tesmer, Rahul Mannan, Xuhong Cao, Pankaj Vats, Sethuramasundaram Pitchiaya, Stephanie J. Ellison, Jiaqi Shi, Chandan Kumar-Sinha, Howard C. Crawford, Arul M. Chinnaiyan
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16309-2

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