An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development
Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is dependent on EGFR/RAS but not AGO2, while AGO2 is requir...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16309-2 |
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doaj-4879439f815846169a9d5e62cae6d7c22021-06-06T11:15:03ZengNature Publishing GroupNature Communications2041-17232020-06-0111111710.1038/s41467-020-16309-2An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer developmentSunita Shankar0Jean Ching-Yi Tien1Ronald F. Siebenaler2Seema Chugh3Vijaya L. Dommeti4Sylvia Zelenka-Wang5Xiao-Ming Wang6Ingrid J. Apel7Jessica Waninger8Sanjana Eyunni9Alice Xu10Malay Mody11Andrew Goodrum12Yuping Zhang13John J. Tesmer14Rahul Mannan15Xuhong Cao16Pankaj Vats17Sethuramasundaram Pitchiaya18Stephanie J. Ellison19Jiaqi Shi20Chandan Kumar-Sinha21Howard C. Crawford22Arul M. Chinnaiyan23Michigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganDepartment of Biological Sciences, Purdue UniversityMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganDepartment of Pathology, University of MichiganMichigan Center for Translational Pathology, University of MichiganDepartment of Molecular and Integrative Physiology, University of MichiganMichigan Center for Translational Pathology, University of MichiganArgonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is dependent on EGFR/RAS but not AGO2, while AGO2 is required for pancreatic ductal adenocarcinoma progression and metastasis.https://doi.org/10.1038/s41467-020-16309-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sunita Shankar Jean Ching-Yi Tien Ronald F. Siebenaler Seema Chugh Vijaya L. Dommeti Sylvia Zelenka-Wang Xiao-Ming Wang Ingrid J. Apel Jessica Waninger Sanjana Eyunni Alice Xu Malay Mody Andrew Goodrum Yuping Zhang John J. Tesmer Rahul Mannan Xuhong Cao Pankaj Vats Sethuramasundaram Pitchiaya Stephanie J. Ellison Jiaqi Shi Chandan Kumar-Sinha Howard C. Crawford Arul M. Chinnaiyan |
| spellingShingle |
Sunita Shankar Jean Ching-Yi Tien Ronald F. Siebenaler Seema Chugh Vijaya L. Dommeti Sylvia Zelenka-Wang Xiao-Ming Wang Ingrid J. Apel Jessica Waninger Sanjana Eyunni Alice Xu Malay Mody Andrew Goodrum Yuping Zhang John J. Tesmer Rahul Mannan Xuhong Cao Pankaj Vats Sethuramasundaram Pitchiaya Stephanie J. Ellison Jiaqi Shi Chandan Kumar-Sinha Howard C. Crawford Arul M. Chinnaiyan An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development Nature Communications |
| author_facet |
Sunita Shankar Jean Ching-Yi Tien Ronald F. Siebenaler Seema Chugh Vijaya L. Dommeti Sylvia Zelenka-Wang Xiao-Ming Wang Ingrid J. Apel Jessica Waninger Sanjana Eyunni Alice Xu Malay Mody Andrew Goodrum Yuping Zhang John J. Tesmer Rahul Mannan Xuhong Cao Pankaj Vats Sethuramasundaram Pitchiaya Stephanie J. Ellison Jiaqi Shi Chandan Kumar-Sinha Howard C. Crawford Arul M. Chinnaiyan |
| author_sort |
Sunita Shankar |
| title |
An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development |
| title_short |
An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development |
| title_full |
An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development |
| title_fullStr |
An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development |
| title_full_unstemmed |
An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development |
| title_sort |
essential role for argonaute 2 in egfr-kras signaling in pancreatic cancer development |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-06-01 |
| description |
Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is dependent on EGFR/RAS but not AGO2, while AGO2 is required for pancreatic ductal adenocarcinoma progression and metastasis. |
| url |
https://doi.org/10.1038/s41467-020-16309-2 |
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