Applications of Macrocyclic Host Molecules in Immune Modulation and Therapeutic Delivery

The immune system plays a central role in the development and progression of human disease. Modulation of the immune response is therefore a critical therapeutic target that enables us to approach some of the most vexing problems in medicine today such as obesity, cancer, viral infection, and autoim...

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Main Authors: Shreya S. Soni, Abdulrahman Alsasa, Christopher B. Rodell
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.658548/full
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spelling doaj-4874e4ecdc704a1ab6800848f64fbad72021-04-06T04:20:42ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-04-01910.3389/fchem.2021.658548658548Applications of Macrocyclic Host Molecules in Immune Modulation and Therapeutic DeliveryShreya S. SoniAbdulrahman AlsasaChristopher B. RodellThe immune system plays a central role in the development and progression of human disease. Modulation of the immune response is therefore a critical therapeutic target that enables us to approach some of the most vexing problems in medicine today such as obesity, cancer, viral infection, and autoimmunity. Methods of manipulating the immune system through therapeutic delivery centralize around two common themes: the local delivery of biomaterials to affect the surrounding tissue or the systemic delivery of soluble material systems, often aided by context-specific cell or tissue targeting strategies. In either case, supramolecular interactions enable control of biomaterial composition, structure, and behavior at the molecular-scale; through rational biomaterial design, the realization of next-generation immunotherapeutics and immunotheranostics is therefore made possible. This brief review highlights methods of harnessing macromolecular interaction for immunotherapeutic applications, with an emphasis on modes of drug delivery.https://www.frontiersin.org/articles/10.3389/fchem.2021.658548/fullmacrocyclepolymerhydrogelnanoparticledrug deliveryimmunotherapy
collection DOAJ
language English
format Article
sources DOAJ
author Shreya S. Soni
Abdulrahman Alsasa
Christopher B. Rodell
spellingShingle Shreya S. Soni
Abdulrahman Alsasa
Christopher B. Rodell
Applications of Macrocyclic Host Molecules in Immune Modulation and Therapeutic Delivery
Frontiers in Chemistry
macrocycle
polymer
hydrogel
nanoparticle
drug delivery
immunotherapy
author_facet Shreya S. Soni
Abdulrahman Alsasa
Christopher B. Rodell
author_sort Shreya S. Soni
title Applications of Macrocyclic Host Molecules in Immune Modulation and Therapeutic Delivery
title_short Applications of Macrocyclic Host Molecules in Immune Modulation and Therapeutic Delivery
title_full Applications of Macrocyclic Host Molecules in Immune Modulation and Therapeutic Delivery
title_fullStr Applications of Macrocyclic Host Molecules in Immune Modulation and Therapeutic Delivery
title_full_unstemmed Applications of Macrocyclic Host Molecules in Immune Modulation and Therapeutic Delivery
title_sort applications of macrocyclic host molecules in immune modulation and therapeutic delivery
publisher Frontiers Media S.A.
series Frontiers in Chemistry
issn 2296-2646
publishDate 2021-04-01
description The immune system plays a central role in the development and progression of human disease. Modulation of the immune response is therefore a critical therapeutic target that enables us to approach some of the most vexing problems in medicine today such as obesity, cancer, viral infection, and autoimmunity. Methods of manipulating the immune system through therapeutic delivery centralize around two common themes: the local delivery of biomaterials to affect the surrounding tissue or the systemic delivery of soluble material systems, often aided by context-specific cell or tissue targeting strategies. In either case, supramolecular interactions enable control of biomaterial composition, structure, and behavior at the molecular-scale; through rational biomaterial design, the realization of next-generation immunotherapeutics and immunotheranostics is therefore made possible. This brief review highlights methods of harnessing macromolecular interaction for immunotherapeutic applications, with an emphasis on modes of drug delivery.
topic macrocycle
polymer
hydrogel
nanoparticle
drug delivery
immunotherapy
url https://www.frontiersin.org/articles/10.3389/fchem.2021.658548/full
work_keys_str_mv AT shreyassoni applicationsofmacrocyclichostmoleculesinimmunemodulationandtherapeuticdelivery
AT abdulrahmanalsasa applicationsofmacrocyclichostmoleculesinimmunemodulationandtherapeuticdelivery
AT christopherbrodell applicationsofmacrocyclichostmoleculesinimmunemodulationandtherapeuticdelivery
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