Protein expression of DNA damage repair proteins dictates response to topoisomerase and PARP inhibitors in triple-negative breast cancer.

Protein expression of DNA damage repair proteins dictates response to topoisomerase and PARP inhibitors in triple-negative breast cancer.

Patients with metastatic triple-negative breast cancer (TNBC) have a poor prognosis. New approaches for the treatment of TNBC are needed to improve patient survival. The concept of synthetic lethality, brought about by inactivating complementary DNA repair pathways, has been proposed as a promising...

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Bibliographic Details
Main Authors: Julie L Boerner, Nicole Nechiporchik, Kelly L Mueller, Lisa Polin, Lance Heilbrun, Scott A Boerner, Gina L Zoratti, Karri Stark, Patricia M LoRusso, Angelika Burger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4361640?pdf=render

Internet

http://europepmc.org/articles/PMC4361640?pdf=render

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