A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone

A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone

Abstract Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) play important roles in bone metabolism. Smad ubiquitination regulatory factors (Smurfs) regulate TGF-β/BMP signaling via ubiquitination, resulting in degradation of signaling molecules to prevent excessive activation...

Full description

Bibliographic Details
Main Authors: Junichi Kushioka, Takashi Kaito, Rintaro Okada, Hiroyuki Ishiguro, Zeynep Bal, Joe Kodama, Ryota Chijimatsu, Melanie Pye, Masahiro Narimatsu, Jeffrey L. Wrana, Yasumichi Inoue, Hiroko Ninomiya, Shin Yamamoto, Takashi Saitou, Hideki Yoshikawa, Takeshi Imamura
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-020-00115-z

Internet

https://doi.org/10.1038/s41413-020-00115-z

Similar Items