Addison's disease and ACTH-producing pituitary microadenoma

A 28-year-old man diagnosed with primary adrenal insufficiency (Addison's disease) in 2002. Following diagnosis, replacement therapy with hydrocortisone and fludrocortisone was indicated. Hydrocortisone replacement therapy was unsuccessful, and increased ACTH levels as high as 996 pg/dl were ob...

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Main Authors:	S.S. Ortega, Y.H. Aguiar, P.P. Marrero, S.M. Casas
Format:	Article
Language:	English
Published:	Permanyer 2015-10-01
Series:	Revista Médica del Hospital General de México
Subjects:	Nelson's syndrome ACTH Addison's disease Autoimmune adrenalitis
Online Access:	http://www.sciencedirect.com/science/article/pii/S0185106315000529

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spelling	doaj-486995968b4d4bc1b84384b32b083f6e2020-11-25T03:21:25ZengPermanyerRevista Médica del Hospital General de México0185-10632015-10-0178417717910.1016/j.hgmx.2015.08.007Addison's disease and ACTH-producing pituitary microadenomaS.S. OrtegaY.H. AguiarP.P. MarreroS.M. CasasA 28-year-old man diagnosed with primary adrenal insufficiency (Addison's disease) in 2002. Following diagnosis, replacement therapy with hydrocortisone and fludrocortisone was indicated. Hydrocortisone replacement therapy was unsuccessful, and increased ACTH levels as high as 996 pg/dl were observed on outpatient follow-up. A pituitary MRI revealed a pituitary microadenoma. These findings raised three possibilities: (1) treatment is insufficient; (2) there is no relationship between Addison's disease and pituitary microadenoma; and (3) the microadenoma is similar to Nelson's syndrome. This latter is the most satisfactory explanation of this patient's clinical picture.http://www.sciencedirect.com/science/article/pii/S0185106315000529Nelson's syndromeACTHAddison's diseaseAutoimmune adrenalitis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	S.S. Ortega Y.H. Aguiar P.P. Marrero S.M. Casas
spellingShingle	S.S. Ortega Y.H. Aguiar P.P. Marrero S.M. Casas Addison's disease and ACTH-producing pituitary microadenoma Revista Médica del Hospital General de México Nelson's syndrome ACTH Addison's disease Autoimmune adrenalitis
author_facet	S.S. Ortega Y.H. Aguiar P.P. Marrero S.M. Casas
author_sort	S.S. Ortega
title	Addison's disease and ACTH-producing pituitary microadenoma
title_short	Addison's disease and ACTH-producing pituitary microadenoma
title_full	Addison's disease and ACTH-producing pituitary microadenoma
title_fullStr	Addison's disease and ACTH-producing pituitary microadenoma
title_full_unstemmed	Addison's disease and ACTH-producing pituitary microadenoma
title_sort	addison's disease and acth-producing pituitary microadenoma
publisher	Permanyer
series	Revista Médica del Hospital General de México
issn	0185-1063
publishDate	2015-10-01
description	A 28-year-old man diagnosed with primary adrenal insufficiency (Addison's disease) in 2002. Following diagnosis, replacement therapy with hydrocortisone and fludrocortisone was indicated. Hydrocortisone replacement therapy was unsuccessful, and increased ACTH levels as high as 996 pg/dl were observed on outpatient follow-up. A pituitary MRI revealed a pituitary microadenoma. These findings raised three possibilities: (1) treatment is insufficient; (2) there is no relationship between Addison's disease and pituitary microadenoma; and (3) the microadenoma is similar to Nelson's syndrome. This latter is the most satisfactory explanation of this patient's clinical picture.
topic	Nelson's syndrome ACTH Addison's disease Autoimmune adrenalitis
url	http://www.sciencedirect.com/science/article/pii/S0185106315000529
work_keys_str_mv	AT ssortega addisonsdiseaseandacthproducingpituitarymicroadenoma AT yhaguiar addisonsdiseaseandacthproducingpituitarymicroadenoma AT ppmarrero addisonsdiseaseandacthproducingpituitarymicroadenoma AT smcasas addisonsdiseaseandacthproducingpituitarymicroadenoma
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Addison's disease and ACTH-producing pituitary microadenoma

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