Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1

Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1

Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine. We studied how the cell of origin contributes to phenotypic heterogeneity following conditional expression of KrasG12D and loss of Lkb1 (Kras;Lkb1). Using progenitor cell-type-restricted adenoviral Cre to targe...

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Bibliographic Details
Main Authors: Ashwini S. Nagaraj, Jenni Lahtela, Annabrita Hemmes, Teijo Pellinen, Sami Blom, Jennifer R. Devlin, Kaisa Salmenkivi, Olli Kallioniemi, Mikko I. Mäyränpää, Katja Närhi, Emmy W. Verschuren
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
non-small-cell lung cancer
Kras
Lkb1
cell-of-origin
club cell
immune microenvironment
tumor-associated neutrophils
adenosquamous
histopathology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716317661

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