Small and Intermediate Calcium-Activated Potassium Channel Openers Improve Rat Endothelial and Erectile Function
Modulation of endothelial calcium-activated potassium (KCa) channels has been proposed as an approach to restore endothelial function. The present study investigated whether novel openers of KCa channels with small (KCa2.x) and intermediate (KCa3.1) conductance, NS309 and NS4591, improve endothelium...
Main Authors: | Simon G. Comerma-Steffensen, Ingrid Carvacho, Elise R. Hedegaard, Ulf Simonsen |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2017-09-01
|
Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2017.00660/full |
Similar Items
-
Activation of SK/KCa Channel Attenuates Spinal Cord Ischemia-Reperfusion Injury via Anti-oxidative Activity and Inhibition of Mitochondrial Dysfunction in Rabbits
by: Jie Zhu, et al.
Published: (2019-04-01) -
Corpus cavernosum electromyography, a usable clinical diagnostic method for erectile dysfunction?
by: Gorm Wagner, et al.
Published: (2006-01-01) -
The role of small and intermediate conductance calcium-activated potassium channels in endothelial-dependent hyperpolarization in physiology and arterial hypertension
by: Monika Kloza, et al.
Published: (2019-01-01) -
The Potassium SK Channel Activator NS309 Protects Against Experimental Traumatic Brain Injury Through Anti-Inflammatory and Immunomodulatory Mechanisms
by: Tao Chen, et al.
Published: (2019-11-01) -
Hypercaloric Diet Establishes Erectile Dysfunction in Rat: Mechanisms Underlying the Endothelial Damage
by: Iara L. L. de Souza, et al.
Published: (2017-10-01)