Autotransporter-Mediated Display of Complement Receptor Ligands by Gram-Negative Bacteria Increases Antibody Responses and Limits Disease Severity

Autotransporter-Mediated Display of Complement Receptor Ligands by Gram-Negative Bacteria Increases Antibody Responses and Limits Disease Severity

The targeting of immunogens/vaccines to specific immune cells is a promising approach for amplifying immune responses in the absence of exogenous adjuvants. However, the targeting approaches reported thus far require novel, labor-intensive reagents for each vaccine and have primarily been shown as p...

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Bibliographic Details
Main Authors: Kristen M Holland-Tummillo, Lauren E Shoudy, Donald Steiner, Sudeep Kumar, Sarah J Rosa, Prachi Namjoshi, Anju Singh, Timothy J Sellati, Edmund J Gosselin, Karsten RO Hazlett
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pathogens
Subjects:
plug &amp
play
vaccine-targeting
gram-negative
complement
autotransporter
Online Access:https://www.mdpi.com/2076-0817/9/5/375

Internet

https://www.mdpi.com/2076-0817/9/5/375

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