Citotoxicity of Fipronil on Hepatocytes Isolated from Rat and Effects of Its Biotransformation

Citotoxicity of Fipronil on Hepatocytes Isolated from Rat and Effects of Its Biotransformation

ABSTRACT The aim of this study was to characterize the mechanism of toxicity of fipronil on hepatocytes isolated from the rat and the effect of its biotransformation on the toxicological potential. The toxicity of fipronil was assessed by monitoring the oxygen consumption and mitochondrial membrane...

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Bibliographic Details
Main Authors: Marieli Guelfi, Marcos Antonio Maioli, Marco Aurélio Tavares, Fábio Erminio Mingatto
Format: Article
Language:English
Published: Instituto de Tecnologia do Paraná (Tecpar) 2015-12-01
Series:Brazilian Archives of Biology and Technology
Subjects:
fipronil
hepatotoxicity
bioenergetics
biotransformation
calcium homeostasis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000600843&lng=en&tlng=en

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