Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis

Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis

Phosphorylation of histone H3 threonine 118 (H3 T118ph) weakens histone DNA-contacts, disrupting the nucleosome structure. We show that Aurora-A mediated H3 T118ph occurs at pericentromeres and chromosome arms during prophase and is lost upon chromosome alignment. Expression of H3 T118E or H3 T118I...

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Bibliographic Details
Main Authors: Candice L Wike, Hillary K Graves, Reva Hawkins, Matthew D Gibson, Michelle B Ferdinand, Tao Zhang, Zhihong Chen, Damien F Hudson, Jennifer J Ottesen, Michael G Poirier, Jill Schumacher, Jessica K Tyler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
aurora-A
histone H3 phosphorylation
cohesion
condensin
chromosome congression
Online Access:https://elifesciences.org/articles/11402

Internet

https://elifesciences.org/articles/11402

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