Bilateral male breast cancer with male potential hypogonadism

<p>Abstract</p> <p>Background</p> <p>Male breast cancer is a comparatively rare disease, and simultaneous bilateral male breast cancer is considered to be an extremely rare event. Risk factors are said to be genetic factors and hormonal abnormalities due to obesity or t...

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Main Authors: Kurokawa Yasushi, Morimoto Tadaoki, Hirose Toshiyuki, Bando Yoshimi, Sasa Mitsunori, Hirose Yukiko, Nagao Taeko, Tangoku Akira
Format: Article
Language:English
Published: BMC 2007-06-01
Series:World Journal of Surgical Oncology
Online Access:http://www.wjso.com/content/5/1/60
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spelling doaj-483eb48b0e7f443393a5c5e08cd07e182020-11-25T02:51:26ZengBMCWorld Journal of Surgical Oncology1477-78192007-06-01516010.1186/1477-7819-5-60Bilateral male breast cancer with male potential hypogonadismKurokawa YasushiMorimoto TadaokiHirose ToshiyukiBando YoshimiSasa MitsunoriHirose YukikoNagao TaekoTangoku Akira<p>Abstract</p> <p>Background</p> <p>Male breast cancer is a comparatively rare disease, and simultaneous bilateral male breast cancer is considered to be an extremely rare event. Risk factors are said to be genetic factors and hormonal abnormalities due to obesity or testicular diseases.</p> <p>Case presentation</p> <p>The patient was a 47-year-old Japanese male. His family had no history of female breast cancer. This patient also had hypospadias and hormonal examination indicated the presence of primary testicular potential hypogonadism, and these hormonal abnormalities seemed to be present since childhood or the fetal period. The bilateral breast cancer developed in this man at a comparatively young age, and histopathological studies of multiple sections showed that there was almost no normal epithelial cell in the ducts, while the ducts were almost completely filled with breast cancer cells.</p> <p>Conclusion</p> <p>It is thought that male breast cancer is caused by an imbalance between estrogen and testosterone. We cannot rule out the possibility that the breast cancer developed due to the effect of the slight elevation of estrogen over a long period of time, but the actual causative factors in this patient were unable to be definitively identified. In the future, we hope to further elucidate the causes of male breast cancer.</p> http://www.wjso.com/content/5/1/60
collection DOAJ
language English
format Article
sources DOAJ
author Kurokawa Yasushi
Morimoto Tadaoki
Hirose Toshiyuki
Bando Yoshimi
Sasa Mitsunori
Hirose Yukiko
Nagao Taeko
Tangoku Akira
spellingShingle Kurokawa Yasushi
Morimoto Tadaoki
Hirose Toshiyuki
Bando Yoshimi
Sasa Mitsunori
Hirose Yukiko
Nagao Taeko
Tangoku Akira
Bilateral male breast cancer with male potential hypogonadism
World Journal of Surgical Oncology
author_facet Kurokawa Yasushi
Morimoto Tadaoki
Hirose Toshiyuki
Bando Yoshimi
Sasa Mitsunori
Hirose Yukiko
Nagao Taeko
Tangoku Akira
author_sort Kurokawa Yasushi
title Bilateral male breast cancer with male potential hypogonadism
title_short Bilateral male breast cancer with male potential hypogonadism
title_full Bilateral male breast cancer with male potential hypogonadism
title_fullStr Bilateral male breast cancer with male potential hypogonadism
title_full_unstemmed Bilateral male breast cancer with male potential hypogonadism
title_sort bilateral male breast cancer with male potential hypogonadism
publisher BMC
series World Journal of Surgical Oncology
issn 1477-7819
publishDate 2007-06-01
description <p>Abstract</p> <p>Background</p> <p>Male breast cancer is a comparatively rare disease, and simultaneous bilateral male breast cancer is considered to be an extremely rare event. Risk factors are said to be genetic factors and hormonal abnormalities due to obesity or testicular diseases.</p> <p>Case presentation</p> <p>The patient was a 47-year-old Japanese male. His family had no history of female breast cancer. This patient also had hypospadias and hormonal examination indicated the presence of primary testicular potential hypogonadism, and these hormonal abnormalities seemed to be present since childhood or the fetal period. The bilateral breast cancer developed in this man at a comparatively young age, and histopathological studies of multiple sections showed that there was almost no normal epithelial cell in the ducts, while the ducts were almost completely filled with breast cancer cells.</p> <p>Conclusion</p> <p>It is thought that male breast cancer is caused by an imbalance between estrogen and testosterone. We cannot rule out the possibility that the breast cancer developed due to the effect of the slight elevation of estrogen over a long period of time, but the actual causative factors in this patient were unable to be definitively identified. In the future, we hope to further elucidate the causes of male breast cancer.</p>
url http://www.wjso.com/content/5/1/60
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AT bandoyoshimi bilateralmalebreastcancerwithmalepotentialhypogonadism
AT sasamitsunori bilateralmalebreastcancerwithmalepotentialhypogonadism
AT hiroseyukiko bilateralmalebreastcancerwithmalepotentialhypogonadism
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