Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets

Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets

Increased availability of large-scale molecular profiling has enabled system-level monitoring of molecular effects of candidate therapeutics. Here, the authors take advantage of such data to show that the ability of a drug to reverse cancer-associated gene expression changes is indicative of itsin v...

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Main Authors: Bin Chen, Li Ma, Hyojung Paik, Marina Sirota, Wei Wei, Mei-Sze Chua, Samuel So, Atul J. Butte
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms16022
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spelling doaj-483c6f7f7ae94ba0a71118ed5cb81f742021-05-11T07:36:21ZengNature Publishing GroupNature Communications2041-17232017-07-018111210.1038/ncomms16022Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targetsBin Chen0Li Ma1Hyojung Paik2Marina Sirota3Wei Wei4Mei-Sze Chua5Samuel So6Atul J. Butte7Department of Pediatrics, Institute for Computational Health Sciences, University of California, San FranciscoDepartment of Surgery, Asian Liver Center, School of Medicine, Stanford UniversityDepartment of Pediatrics, Institute for Computational Health Sciences, University of California, San FranciscoDepartment of Pediatrics, Institute for Computational Health Sciences, University of California, San FranciscoDepartment of Surgery, Asian Liver Center, School of Medicine, Stanford UniversityDepartment of Surgery, Asian Liver Center, School of Medicine, Stanford UniversityDepartment of Surgery, Asian Liver Center, School of Medicine, Stanford UniversityDepartment of Pediatrics, Institute for Computational Health Sciences, University of California, San FranciscoIncreased availability of large-scale molecular profiling has enabled system-level monitoring of molecular effects of candidate therapeutics. Here, the authors take advantage of such data to show that the ability of a drug to reverse cancer-associated gene expression changes is indicative of itsin vitroanti-proliferative efficacy, allowing them to identify novel compounds against liver cancer.https://doi.org/10.1038/ncomms16022
collection DOAJ
language English
format Article
sources DOAJ
author Bin Chen
Li Ma
Hyojung Paik
Marina Sirota
Wei Wei
Mei-Sze Chua
Samuel So
Atul J. Butte
spellingShingle Bin Chen
Li Ma
Hyojung Paik
Marina Sirota
Wei Wei
Mei-Sze Chua
Samuel So
Atul J. Butte
Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
Nature Communications
author_facet Bin Chen
Li Ma
Hyojung Paik
Marina Sirota
Wei Wei
Mei-Sze Chua
Samuel So
Atul J. Butte
author_sort Bin Chen
title Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
title_short Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
title_full Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
title_fullStr Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
title_full_unstemmed Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
title_sort reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-07-01
description Increased availability of large-scale molecular profiling has enabled system-level monitoring of molecular effects of candidate therapeutics. Here, the authors take advantage of such data to show that the ability of a drug to reverse cancer-associated gene expression changes is indicative of itsin vitroanti-proliferative efficacy, allowing them to identify novel compounds against liver cancer.
url https://doi.org/10.1038/ncomms16022
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AT lima reversalofcancergeneexpressioncorrelateswithdrugefficacyandrevealstherapeutictargets
AT hyojungpaik reversalofcancergeneexpressioncorrelateswithdrugefficacyandrevealstherapeutictargets
AT marinasirota reversalofcancergeneexpressioncorrelateswithdrugefficacyandrevealstherapeutictargets
AT weiwei reversalofcancergeneexpressioncorrelateswithdrugefficacyandrevealstherapeutictargets
AT meiszechua reversalofcancergeneexpressioncorrelateswithdrugefficacyandrevealstherapeutictargets
AT samuelso reversalofcancergeneexpressioncorrelateswithdrugefficacyandrevealstherapeutictargets
AT atuljbutte reversalofcancergeneexpressioncorrelateswithdrugefficacyandrevealstherapeutictargets
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