<i>Staphylococcus aureus</i> RnpA Inhibitors: Computational-Guided Design, Synthesis and Initial Biological Evaluation

<i>Staphylococcus aureus</i> RnpA Inhibitors: Computational-Guided Design, Synthesis and Initial Biological Evaluation

Antibiotic resistance is spreading worldwide and it has become one of the most important issues in modern medicine. In this context, the bacterial RNA degradation and processing machinery are essential processes for bacterial viability that may be exploited for antimicrobial therapy. In <i>Sta...

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Bibliographic Details
Main Authors: Lorenzo Suigo, Michaelle Chojnacki, Carlo Zanotto, Victor Sebastián-Pérez, Carlo De Giuli Morghen, Andrea Casiraghi, Paul M. Dunman, Ermanno Valoti, Valentina Straniero
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antibiotics
Subjects:
antibiotic resistance
RnpA inhibitors
MRSA
UAMS-1
RNA degradation machinery
antimicrobial activity
Online Access:https://www.mdpi.com/2079-6382/10/4/438

Internet

https://www.mdpi.com/2079-6382/10/4/438

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